Sri Lochana Das Thakura was born in a family of brahmanas in Burdhaman district of Bengal in 1520. His father was Sri Kamalakara Dasa and mother, Sri Sadanandi. Being their only son, he spent much of his youth living at the home of his grandparents, where he began his education.

While still a young boy, Lochana Dasa met devotees of Lord Chaitanya. He had great attachment for the Lord and was detached from worldly enjoyment. He accepted Sri Narahari Sarakara, an intimate associate of Lord Chaitanya, as his spiritual master. Lochana Dasa writes, "My hope of hopes is to be near the lotus feet of Sri Narahari Thakura, to serve and worship with my very life. My lord is Sri Narahari Thakura, and I am his servant. Bowing and praying before him, I beg him to allow me his service. This is my only aspiration."

Sri Narahari Thakura was an expert composer of devotional songs, and he instructed Lochana Dasa in that art. Lochana Dasa wrote many songs (some of which are found in ISKCON songbooks) and a book about Lord Chaitanya, called Chaitanya Mangala. To write Chaitanya Mangala, Lochana Dasa took inspiration from a Sanskrit book by Sri Murari Gupta, titled Sri Krishna-Chaitanya-Charita.

Lochana Dasa writes, "That very Murari Gupta who lived in Nadiya composed many Sanskrit verses about the life of Sri Gauranga, which he later arranged in the form of a book. Having heard these verses from Murari Gupta, Damodara Pandita taught them to me, and I memorized them with great delight. As these Sanskrit verses and the conception of Chaitanya Mahaprabhu developed in my mind, they flowed forth from me in the form of these Panchali verses in Bengali, which I write in glorification of the life and pastimes of Sri Chaitanya." (Panchali is the classic form of rhymes and meters used by Bengali poets to compose sacred songs and verses. It employs five kinds of song styles).

In Chaitanya Mangala, Srila Lochana Dasa elaborates some of the pastimes of Lord Chaitanya mentioned only briefly by the Lord's two main biographers, Srila Krishnadasa Kaviraja Gosvami and Srila Vrindavana Dasa Thakura.

Srila Lochana Dasa Thakura left this world in 1618 to enter the Lord's eternal pastimes.